Itaconic Acid: The Bio-Based Alternative to Fossil Acrylates
Quick answer: Itaconic acid is a five-carbon dicarboxylic acid made by fermenting sugar with fungi. It has one radically polymerizable terminal alkene and[…]
Itaconic Acid: The Immune Metabolite Your Body Produces to Fight Disease
If you work in polymer chemistry, you already know itaconic acid. It is a workhorse industrial compound, a dicarboxylic acid with a double[…]
How Itaconate Modifications Control Inflammation and Could Transform Disease Treatment
If you told a biologist 15 years ago that a byproduct of the citric acid cycle could shut down inflammation, they’d probably raise[…]
iNOS suppresses itaconate by directly binding IRG1 in mitochondria, no nitric oxide required
There’s a protein in your immune cells that most biochemistry textbooks treat as well-understood. It’s called inducible nitric oxide synthase, or iNOS, and[…]
Itaconate: A Metabolite Driving One of the Deadliest Brain Tumors
Brain tumors are tough to treat. ZFTA-RELA fusion-positive ependymomas are among the worst—affecting mostly children and young adults with few options beyond surgery[…]