4-Hydrazinobenzenesulfonamide Hydrochloride
CAS RN: 17852-52-7 | Product of Symb ChemTech
Chemical Overview
This section provides a high-level introduction to 4-Hydrazinobenzenesulfonamide Hydrochloride. You’ll find its fundamental chemical properties and a visual representation of its structure, offering a quick summary for immediate identification and context before you explore its specific uses and technical details.
- Molecular Formula C₆H₁₀ClN₃O₂S
- Molecular Weight 223.68 g/mol
- Synonyms p-Hydrazinobenzenesulfonamide HCl
This compound is a key intermediate in pharmaceutical and fine chemical synthesis. It features both a hydrazine and a sulfonamide group, making it a versatile building block for diverse organic reactions. Its hydrochloride salt form ensures enhanced stability and easier handling.
Conceptual Molecule Animation
Interactive Applications Explorer
Explore the diverse industrial applications of this versatile compound. Click on any of the cards below to reveal its specific uses within that sector. This interactive format allows you to focus on the areas most relevant to your research or production needs, from pharmaceuticals to agrochemicals.
Select an application above to see details.
Technical Specifications & Quality
This area details the quality and technical specifications of the product supplied by Symb ChemTech. Here you can review the guaranteed purity level, the methods used for quality control, and the documentation provided with every order, ensuring the product meets the stringent requirements of your application.
Quality Assurance
- Consistent Quality: Each batch undergoes strict quality control to guarantee reproducibility.
- Rigorous Testing: Analysis performed via HPLC, GC, NMR, and Mass Spectrometry.
- Detailed Documentation: A comprehensive Certificate of Analysis (CoA) and MSDS are provided.
- Flexible Packaging: Available in various sizes, from lab scale to bulk industrial quantities.
About the Supplier: Symb ChemTech
Learn why Symb ChemTech is the preferred partner for high-purity chemical intermediates. This section highlights the company’s commitment to quality, manufacturing expertise, and customer-focused approach, giving you confidence in the reliability of your supply chain.
Unwavering Commitment to Quality
We adhere to strict quality management systems, including ISO guidelines, to ensure every product exceeds expectations.
Expertise in Synthesis
Our team of experienced chemists and state-of-the-art facilities enable efficient and scalable production of complex compounds.
Global Reach & Logistics
Efficient supply chain management ensures timely and secure delivery worldwide.
Customer-Centric Approach
We work closely with our clients to understand their specific needs and provide tailored solutions.
4-Hydrazinobenzenesulfonamide Hydrochloride (CAS 17852-52-7) is a high-value pharmaceutical intermediate essential for synthesizing Celecoxib, a leading selective COX-2 inhibitor used to treat arthritis and acute pain. Produced by Symb ChemTech, a global leader in fine chemicals since 1999, this compound exemplifies precision-driven chemical innovation. This article explores its chemical profile, synthesis, applications, and why Symb ChemTech is the trusted partner for pharmaceutical manufacturers.
Chemical Profile & Applications
Key Specifications
- CAS Number: 17852-52-7
- IUPAC Name: 4-Hydrazinylbenzenesulfonamide Hydrochloride
- Appearance: White to off-white crystalline powder
- Purity: ≥98% (industrial grade)
Core Applications
- Celecoxib Synthesis: The primary intermediate in the production of Celecoxib, a blockbuster NSAID with superior gastrointestinal safety profiles.
- Other COX-2 Inhibitors: Serves as a building block for related diarylheterocycle-based therapeutics.
- Research & Development: Widely used in medicinal chemistry for novel anti-inflammatory and analgesic drug discovery.
Symb ChemTech’s Proven Synthesis Process
Symb ChemTech employs a three-stage industrial process to ensure high yield and purity:
1. Diazotization
- Raw Material: Sulfanilamide (p-aminobenzenesulfonamide)
- Reaction: Treated with sodium nitrite under acidic conditions at -5°C to 5°C to form a stable diazonium salt.
2. Reduction
- Step: The diazonium salt is reduced using sodium sulfite (Na₂SO₃) under controlled pH and temperature (≤35°C).
- Key Innovation: Proprietary catalysts enhance reaction efficiency, achieving 99% conversion rates.
3. Hydrochloride Salt Formation
- Purification: The crude product undergoes methanol washing and vacuum drying to yield high-purity hydrazine salt.
- Quality Control: Stringent testing for residual solvents and heavy metals ensures compliance with ICH Q3D guidelines.
Why Symb ChemTech Stands Out
20+ Years of Expertise
As a Shanghai-based high-tech enterprise, Symb ChemTech combines decades of experience in:
- Polyurethane curatives
- Fine chemicals
- Biochemical intermediates
Commitment to Quality & Sustainability
- Green Chemistry: Processes designed to minimize waste and energy consumption.
- Certifications: Adheres to ISO, REACH, and FDA standards.
- Scalability: 500+ ton annual production capacity for reliable bulk supply.