1. Technical Specifications & Chemical Properties
Understanding the precise physical and chemical parameters of your synthesis precursors is vital to maintaining batch-to-batch consistency in clinical chemistry and development.
Below are the analytical properties of the compound supplied by Symb ChemTech:
| Parameter | Specification & Chemical Identity |
|---|---|
| Systematic (IUPAC) Name | [(7α,17β)-7-(9-bromononyl)-3-hydroxyestra-1,3,5(10)-trien-17-yl] acetate |
| CAS Registry Number | 875573-66-3 |
| Molecular Formula | C₂₉H₄₃BrO₃ |
| Molecular Weight | 519.56 g/mol |
| Appearance | White to off-white crystalline powder or viscous mass |
| Purity (HPLC) | ≥ 98.0% (Custom high-purity batches available up to 99.5%) |
| Solubility | Soluble in chloroform, ethyl acetate, and dimethyl sulfoxide (DMSO); practically insoluble in water |
| Storage Conditions | Store at -20°C under an inert gas atmosphere (nitrogen/argon), protected from moisture and direct light |
2. Key Applications: Why CAS 875573-66-3 is Vital in Pharmaceutical R&D
The chemical structure of (7a,17b)-7-(9-Bromononyl)-estra-1,3,5(10)-triene-3,17-diol 17-acetate makes it uniquely valuable for complex steroid functionalization.
A. Intermediate for Selective Estrogen Receptor Degraders (SERDs)
In modern oncology research, targeting estrogen receptor-positive (ER+) breast cancer pathways is highly dependent on SERDs. This compound serves as a primary regulatory precursor in the synthesis of Fulvestrant and related derivatives. The 9-bromononyl side chain at the $7\alpha$-position provides an ideal electrophilic site for nucleophilic displacement, enabling scientists to attach the precise organosulfur or fluorinated tail groups required for active drug targets.
B. Steroid Functionalization Precursor
The molecule retains the essential cyclopentanophenanthrene core of estradiol but features strategic protective acetylation at the $17\beta$-hydroxyl group and a highly reactive bromine atom at the terminus of the nonyl chain. This structural balance allows synthetic chemists to perform highly selective reactions on the $7\alpha$ chain without degrading or altering the $17\beta$ and $3$-position hydroxyl configurations.
C. Academic and Clinical Estrogen Research
Beyond oncology therapeutic pathways, CAS 875573-66-3 is actively utilized as an analytical standard and reactant in endocrine system studies, estrogen receptor mapping, and custom bio-conjugation assays.
3. The Advantage of Sourcing from Symb ChemTech
When procuring complex steroid intermediates, impurities can compromise down-stream synthesis yields and complicate purification protocols. Symb ChemTech mitigates these risks by implementing clinical-grade quality protocols across our entire production line.
- Rigorous Analytical Verification: Every batch of CAS 875573-66-3 is accompanied by a comprehensive Certificate of Analysis (CoA), including High-Performance Liquid Chromatography (HPLC) profiles, Proton Nuclear Magnetic Resonance ($^1\text{H-NMR}$) mapping, and Mass Spectrometry (MS) verification.
- Scale Flexibility: Whether your pipeline requires milligram scales for initial pilot laboratory testing or multi-kilogram quantities for pilot plant trials, our synthesis capacity seamlessly scales to match your project’s lifecycle.
- Global Logistics & Compliance: We provide robust compliance support, securing international chemical shipping documentation, customs clearance parameters, and hazardous material transport security to deliver your materials safely anywhere in the world.
- Optimal Stability and Packaging: To prevent degradation of the active halogen alkyl chain during transit, we ship our materials in specialized, light-shielded, moisture-barrier, and temperature-controlled packaging.
4. Frequently Asked Questions (FAQ) for Procurement & Technical Teams
How does the 17-acetate group affect the compound’s reactivity?
The 17-acetate group acts as a protective ester for the $17\beta$-hydroxyl group. This prevents unwanted side reactions at the 17-position while chemists manipulate the reactive terminal bromine on the $7\alpha$-(9-bromononyl) chain. Once the side chain modifications are complete, the acetate can be easily hydrolyzed back to the free hydroxyl group under mild basic conditions.
Can Symb ChemTech customize purity and packaging options?
Yes. We specialize in custom-tailoring chemical specifications. If your synthetic process demands ultra-high purity (≥99%), low moisture content, or custom packaging options under nitrogen purge, our technical team will manufacture to meet your specific standard operating procedures (SOPs).
What is the lead time for global shipments?
For in-stock batches, domestic and international dispatches are processed within 24–48 hours. For bulk requirements or custom synthesis campaigns, lead times are discussed transparently and coordinated closely with your procurement timeline.
Contact Symb ChemTech for Pricing & Documentation
Ensure the success of your developmental pipeline by integrating reliable, high-purity chemical intermediates. Contact Symb ChemTech today to request a quote, secure a Certificate of Analysis (CoA), or speak directly with our synthetic chemistry team.
- Official Website: symbchem.com
- Inquiries & Technical Support: Contact us through our online portal to speak with an account manager who understands your industry’s standards.